Journal article
Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
MD Walsh, MC Cummings, SA Pearson, M Clendenning, RJ Walters, B Nagler, JL Hopper, MA Jenkins, GK Suthers, J Goldblatt, K Tucker, MR Gattas, JL Arnold, S Parry, FA Macrae, MA Mcguckin, JP Young, DD Buchanan
Modern Pathology | NATURE PUBLISHING GROUP | Published : 2013
Abstract
Mismatch repair-deficient breast cancers may be identified in Lynch syndrome mutation carriers, and have clinicopathological features in common with mismatch repair-deficient colorectal and endometrial cancers such as tumour-infiltrating lymphocytes and poor differentiation. Mismatch repair-deficient colorectal cancers frequently show mucinous differentiation associated with upregulation of chromosome 11 mucins. The aim of this study was to compare the protein expression of these mucins in mismatch repair-deficient and -proficient breast cancers. Cases of breast cancer (n=100) were identified from families where (1) both breast and colon cancer co-occurred and (2) families met either modifie..
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Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA no. CA-95-011 and through the Australasian Colorectal Cancer Family Registry cooperative agreement (U01 CA097735). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the CFRs, nor does mention of trade names, commercial products or organisations imply endorsement by the US Government or the CFR. Breast tissue samples in this study were obtained from the Jeremy Jass Memorial Tissue Pathology Bank. We are also grateful to the many pathology laboratories involved for supply of extra archived breast tissue for analysis. We thank Judi Maskiell, Leanne Prior, Kelly Aujard, Erika Pavluk and Maggie Angelakos for data and pedigree retrieval, and to members of the families who have given significant time and effort to the contribution of data. During this study, Joanne Young was a Cancer Council Queensland Senior Research Fellow, and Michael McGuckin is supported by an NHMRC Senior Research Fellowship.